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Psoriatic Arthritis - New Study 2021

 Psoriatic arthritis  is a heterogeneous disease that affects multiple organ systems including the peripheral and axial joints, entheses and nails. PsA is associated with significant comorbidities including cardiovascular, metabolic, and psychiatric diseases. The pathogenesis of PsA is complex and involves genetic, immunologic and environmental factors. Recent evidence suggests the heritability for PsA to be stronger and distinct from that of PsC. Prominent genes identified via GWAS for PsA include HLA-B/C, HLAB, IL12B, IL23R, TNP1, TRAF3IP3, and REL. We review the genetics of psoriatic arthritis and discuss the role of the innate immune system as important in the pathogenesis of PsA by focusing on key signaling pathways and cellular makeup. Understanding the candidate genes identified in PsA highlights pathways of critical importance to the pathogenesis of psoriatic disease including the key role of the innate immune response, mediated through IL-23/IL-17 axis, RANK and NFκB...

How to Lose 140 Pounds in 10 Months - Kathryn's Success Story

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 Kathryn Mulkern would tuck into a sausage and egg McMuffin for breakfast every day before gorging on 20 McNuggets, a double cheeseburger and large fries for her dinner. The 39-year-old office worker lulled herself into thinking that skipping lunch was a healthy option. But she soon suffered from bouts of depression and anxiety as she piled on the pounds.    Sometimes she would vary her diet with the occasional Burger King meal. It was only when she visited her doctor that Kathryn was given a stark, but necessary, wake-up call. She was eating her way to an early death. The medic warned her that her blood pressure had sky-rocketed to an all-time high and her cholesterol levels were reaching dangerous levels.  Determined to do something about her poor health and obesity , she signed up to custom Keto Diet in 2019 ( *** Read more : What is Keto Diet - How to Start Keto Diet Safely ) . And 10 months later, she has lost 140 pounds and found a new obsession...

How to Lose 140 Pounds in 10 Months - Kathryn's Story

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  Kathryn Mulkern would tuck into a sausage and egg McMuffin for breakfast every day before gorging on 20 McNuggets, a double cheeseburger and large fries for her dinner. The 39-year-old office worker lulled herself into thinking that skipping lunch was a healthy option. But she soon suffered from bouts of depression and anxiety as she piled on the pounds. Sometimes she would vary her diet with the occasional Burger King meal. It was only when she visited her doctor that Kathryn was given a stark, but necessary, wake-up call. She was eating her way to an early death. The medic warned her that her blood pressure had sky-rocketed to an all-time high and her cholesterol levels were reaching dangerous levels.  Determined to do something about her poor health and obesity , she signed up to custom Keto Diet in 2019. And 10 months later, she has lost 140 pounds and found a new obsession - the gym. She's lost an incredible nine stone and five pounds and dropped six dress size...

How to Lose 350 Pounds Fast - Sharon's Success Story

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Sharon Blakemore admits she had problems with her weight, stretching back to her childhood. When the 39-year-old was still at school she had to wear men's shirts as part of her uniform to fit her 20-inch collar. By the time she was an adult, Sharon was forced to wear mens 8XL clothes to fit her size 38 frame. But when she lost both her parents to cancer within 18 months of each other, Sharon made a solemn vow to each of them that she would fight the flab. Sharon, from California says she had eaten two pies every day from the age of 15 and was a big fan of takeaways. At her heaviest, she weighed almost 530 pounds but is now just 180 pounds and a size 10.She lost total 350 pounds in just 11 months. ! Sharon celebrated her huge achievement with a tattoo that inking artists had originally told her she was too fat to have. Former shopkeeper and stay-at-home mum Sharonsaid: "I've had people that haven't seen me in years following me around the supermarket trying to w...

Best Way to Lose 40 Pounds Fast in 2 Months - Sarah's Success Story

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Sarah Cunnington, 43, from Austin, Texas, dropped from a dress size 22 to a 12, after John, six, spotted her wearing an orange t-shirt. He yelled 'mummy you could be a pumpkin' - and those words changed her life. She has spent her whole adult life trying to lose weight but nothing worked until she signed up for Custom Keto Diet. Sarah now says she couldn't feel any less like a 'pumpkin' and can't wait to show off her svelte figure this Halloween .  She said: "It was just after Halloween, we were looking at photos my friend had put on Facebook when I heard little voice over my shoulder. John looked at the photo and just said 'woo mummy you look like a big pumpkin!' . John is autistic and children can't lie at the best of times but his comment did hurt my feelings" "That was what motivated me to start Custom Keto Diet - before that I had tried everything to lose weight, but I wasn't losing anything. I was a dress size 22 and wi...

Best Way to Lose 80 Pounds in 3 Months - Success's Story

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Jackie Burrows, 53, shed the weight by following Keto Diet and exercising. Ms Burrows, from Brisbane, Australia, piled on the pounds after having four children - leaving her no time to look after herself. When she hit 127kg and a size 22, the mum decided to make a change.She heard about a friend losing more than 70 pounds through Keto and decided to give it a go. She said: "I had never tried Keto or program weight loss. I didn't want to get fixed into weight loss programs and I didn't want to be noticed as a failure.After replacing her breakfast with a Keto meals  she started to see results - and eventually switched to two meal replacement drinks a day"  The mother also adopted a healthy lifestyle, increasing her exercise.  After 3 months, she lost total 80 pounds. The Australian claims to have never felt happier and is confident she will keep the weight off  Read more : Fans Fame Of Keto Diet Include Kim Kardashian, Lebron Jame, Halle Berry, Vinny Guadagnin...